Key result
Overexpression of miR-133 significantly improved cardiac function (LVEF and FS), increased swimming time, and reduced myocardial infarction area in mice with myocardial infarction (p<0.05).
Why the study?
This study aimed to investigate the expression of miR-133 in animal models of myocardial infarction and its effect on cardiac function.
Does overexpression of miR-133 improve cardiac function and reduce infarct size in a mouse model of myocardial infarction?
Does overexpression of miR-133 improve cardiac function and reduce infarct size in a mouse model of myocardial infarction?
p-value: p=<0.05
Overexpression of miR-133 improves cardiac function and reduces infarct size in a mouse model of myocardial infarction, suggesting a potential molecular therapeutic target.
miR-133 overexpression merits further preclinical testing in MI; leaves open any role in human therapy.
No takes yet. Share an insight, caveat, or question.
Zhang et al. (2019) studied Myocardial infarction (n=45). Adenovirus carrying miRNA-133 vs. Empty viral vectors and untreated model group was evaluated on Cardiac function (LVEF and FS) and myocardial infarction area (p=<0.05). Overexpression of miR-133 significantly improved cardiac function (LVEF and FS), increased swimming time, and reduced myocardial infarction area in mice with myocardial infarction (p<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: