What question did this study set out to answer?

To compare the osteogenic potential and candidate gene expression around implants augmented with autograft, xenograft, or synthetic graft materials in canine bone defects.

January 1, 2026Journal of Long-Term Effects of Medical Implants

Osteogenesis potential of different graft materials around dental implants: An animal study

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Authors

MGMahdi GholamiMashhad University of Medical Sciences SPSolmaz PourgonabadiMassachusetts General Hospital CBChristoph BourauelUniversity Hospital Bonn

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Implication

Animal study reveals equivalent osteogenic gene expression across autograft, xenograft, and synthetic grafts in dogs, suggesting synthetic and animal-derived grafts are viable alternatives.

Key Points

To compare the osteogenic potential and candidate gene expression around implants augmented with autograft, xenograft, or synthetic graft materials in canine bone defects.
Extensive sternal osteotomies were prepared and implants were placed in 13 dogs, with peri-implant gaps grafted using autograft, xenograft (Cerabone®), or synthetic graft (Osteon II).
Animals were sacrificed at 2, 4, or 6 months post-implantation to resect peri-implant bone blocks.
Real-time polymerase chain reaction (RT-PCR) was performed to measure the expression of osteogenic markers (RUNX2, ALP, BMP7, and BGLAP), analyzed via two-way ANOVA.
Two-way ANOVA manifested no significant interaction between graft materials and healing intervals (P > 0.05).
No statistically significant differences occurred among autograft, xenograft, and synthetic grafts regarding the expression of ALP, RUNX2, BMP7, and BGLAP (P > 0.05).
Expression levels of candidate osteogenesis genes showed no statistically significant differences between the 2-, 4-, and 6-month healing groups (P > 0.05).

Cite This Study

Gholami et al. (2026) studied this question.

synapsesocial.com/papers/6a844db9880bd6494af7ad46 https://doi.org/10.1615/jlongtermeffmedimplants.2025056690

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Implication

Animal study reveals equivalent osteogenic gene expression across autograft, xenograft, and synthetic grafts in dogs, suggesting synthetic and animal-derived grafts are viable alternatives.

Osteogenesis potential of different graft materials around dental implants: An animal study

Discussion

Member takes

Implication

Key Points

Cite This Study

Osteogenesis potential of different graft materials around dental implants: An animal study

Discussion

Member takes

Implication

Key Points

Cite This Study

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