Key result
Steady flow induced NO-dependent dilation in porcine coronary arterioles, whereas oscillating flow suppressed vasodilation due to NO quenching by superoxide, which was reversed by superoxide dismutase.
Population
Isolated, cannulated subendocardial and subepicardial porcine arterioles
Comparison
Steady flow and oscillating flow, with and… vs Steady flow versus oscillating flow
Design
Preclinical
Authors
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Should not change practice; leaves open whether NO/superoxide modulation improves coronary arteriolar function in humans.
In porcine coronary arterioles, oscillating flow suppresses NO-mediated vasodilation due to quenching by superoxide, suggesting that modulating the NO/superoxide balance could improve subendocardial perfusion.
Sorop et al. (2003) studied this question. Steady versus oscillating flow was evaluated on Vessel dilation. Steady flow induced NO-dependent dilation in porcine coronary arterioles, whereas oscillating flow suppressed vasodilation due to NO quenching by superoxide, which was reversed by superoxide dismutase.
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