Key result
High-sensitivity C-reactive protein (hsCRP) levels driven by transient acute inflammation and lack of detailed smoking data may distort estimations of long-term cardiovascular risk in women.
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This letter raises methodological concerns regarding a recent analysis of biomarkers and 30-year cardiovascular outcomes in women, specifically regarding transient acute inflammation and smoking data.
To the Editor: Ridker et al. (Dec. 5 issue) 1 conducted an important analysis of inflammation, cholesterol, and lipoprotein(a) as predictors of long-term cardiovascular outcomes in women. Of concern is the uncertainty regarding how to address extremely high levels of high-sensitivity C-reactive protein (hsCRP) that may be driven by transient acute inflammation. First, because acute inflammation is often temporary, such values could distort estimations of long-term risk. Second, although adjustments were made for smoking status (defined as current, past, or never), the absence of detailed data regarding smoking intensity and duration limits the analysis. Sensitivity analyses restricted to women who never . . .
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Pei et al. (2025) conducted a letter in Cardiovascular outcomes. Inflammation, cholesterol, and lipoprotein(a) was evaluated on Long-term cardiovascular outcomes. High-sensitivity C-reactive protein (hsCRP) levels driven by transient acute inflammation and lack of detailed smoking data may distort estimations of long-term cardiovascular risk in women.
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