Key result
Bioinformatics analysis identified 385 up- and 504 down-regulated differentially expressed genes in AMI patients compared to normal controls, highlighting CCL5, BCL3, NR2C2, MAX, GTF3C2, and NCOA7.
Population
Peripheral blood samples from 31 first-time acute myocardial infarction patients within 48-h post-MI and 21…
Design
Other
Authors
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Hypothesis-generating for gene targets in AMI; leaves open any clinical role pending validation.
Case-Control (n=52)
Bioinformatics analysis identifies key genes and transcription factors, including CCL5 and several others, that may play important roles in the development of acute myocardial infarction.
Gao et al. (2016) conducted a case-control in Acute myocardial infarction (n=52). Acute myocardial infarction vs. Normal controls was evaluated on Differentially expressed genes (DEGs). Bioinformatics analysis identified 385 up- and 504 down-regulated differentially expressed genes in AMI patients compared to normal controls, highlighting CCL5, BCL3, NR2C2, MAX, GTF3C2, and NCOA7.
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