Key result
Adult-onset inducible expression of TAK1ΔN protected the myocardium from adverse remodeling and heart failure after myocardial infarction or long-term pressure overload by preventing cardiac cell death and fibrosis.
p-value: p=<0.05
Activation of TAK1 in the adult heart promotes adaptive cardiac hypertrophy and protects against adverse remodeling and heart failure following pathological stress.
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TAK1 activation may protect adult myocardium from remodeling in animal models; leaves open clinical translation for MI or pressure-overload HF.
Li et al. (2015) studied Cardiac hypertrophy and heart failure. Inducible cardiac-specific expression of TAK1ΔN vs. Control mice (Wild-type, single transgenic, or Dox-treated) was evaluated on Cardiac hypertrophy, adverse remodeling, and survival following pathological stress (TAC or MI) (p=<0.05). Adult-onset inducible expression of TAK1ΔN protected the myocardium from adverse remodeling and heart failure after myocardial infarction or long-term pressure overload by preventing cardiac cell death and fibrosis.
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