Why the study?
Does circadian time affect ACE activity in serum and lung tissue of normotensive and spontaneously hypertensive rats?
Population
Normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR)
Comparison
Evaluation of ACE activity at six different… vs Comparison between WKY and SHR strains, and…
Design
Preclinical
Follow-up
24 hours
Authors
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Does not support ACE circadian variation as BP regulator in rat models; leaves open human chronotherapy relevance.
Does circadian time affect ACE activity in serum and lung tissue of normotensive and spontaneously hypertensive rats?
Circadian changes in serum and tissue ACE activity are unlikely to play an important role in regulating the circadian blood pressure profile in normotensive and spontaneously hypertensive rats.
Stȩpień et al. (1993) studied this question.
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