Key result
Moderate-to-high levels of anticardiolipin antibodies were significantly associated with preeclampsia (OR 2.86; 95% CI 1.37-5.98) and severe preeclampsia (OR 11.15; 95% CI 2.66-46.75).
Why the study?
Are moderate-to-high levels of anticardiolipin antibodies associated with preeclampsia in pregnant women without autoimmune diseases?
Meta-Analysis
Are moderate-to-high levels of anticardiolipin antibodies associated with preeclampsia in pregnant women without autoimmune diseases?
Odds Ratio: 2.86 (95% CI 1.37–5.98)
Moderate-to-high levels of anticardiolipin antibodies are associated with an increased risk of preeclampsia and severe preeclampsia, though evidence is insufficient for routine clinical prediction.
Insufficient for routine prediction; leaves open prospective validation of anticardiolipin testing in preeclampsia risk stratification.
OBJECTIVE: To systematically review the evidence of the association of anticardiolipin antibodies with preeclampsia. DATA SOURCES: PubMed and LILACS were perused up to June 2009, citations were searched using the ISI Web of Knowledge database, textbooks and reference lists were reviewed, and experts were contacted. Search terms included "antiphospholipid syndrome," "Hughes' syndrome," "anticardiolipin antibodies," "antiphospholipid antibodies," "anti-cardiolipin," "preeclampsia," and "pre-eclampsia." METHODS OF STUDY SELECTION: Inclusion criteria were: cohorts, case-control, or controlled cross-sectional studies; healthy pregnancy as controls; no autoimmune diseases; immunoglobulin (Ig)G, IgM anticardiolipin antibody of at least 20 units by enzyme-linked immunosorbent assay, or both; and end-point preeclampsia. TABULATION, INTEGRATION, AND RESULTS: Our search generated 68,528 entries and 64 full-text articles were reviewed. Twelve studies were included in the meta-analysis. Pooled odds ratio (OR) for association of anticardiolipin antibodies with preeclampsia was 2.86 (95% confidence interval [CI], 1.37-5.98). Pooled OR for anticardiolipin antibodies and severe preeclampsia was 11.15 (95% CI 2.66-46.75). Funnel plot showed minor asymmetry, and the Egger test was not significant (P=.359). Meta-regression identified study design and size as related to heterogeneity. CONCLUSION: Moderate-to-high levels of anticardiolipin antibodies are associated with preeclampsia, but there is insufficient evidence to use anticardiolipin antibodies as predictors of preeclampsia in clinical practice.
No takes yet. Share an insight, caveat, or question.
Prado et al. (2010) conducted a meta-analysis in Preeclampsia. Anticardiolipin antibodies vs. Healthy pregnancy as controls was evaluated on Preeclampsia (OR 2.86, 95% CI 1.37-5.98). Moderate-to-high levels of anticardiolipin antibodies were significantly associated with preeclampsia (OR 2.86; 95% CI 1.37-5.98) and severe preeclampsia (OR 11.15; 95% CI 2.66-46.75).
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: