Key result
Target-specific oral anticoagulants require specific institutional protocols for emergency reversal and bleeding management until comprehensive clinical guidelines are developed.
Population
Patients undergoing anticoagulation with target-specific oral anticoagulants who require emergency treatment…
Design
Review
Authors
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Institutions should consider interim protocols for target-specific oral anticoagulant reversal; leaves open optimal strategies pending randomized data and guidelines.
This review highlights the pharmacologic properties of newer oral anticoagulants and emphasizes the need for institutional protocols to manage bleeding and emergency reversal until comprehensive clinical guidelines are developed.
W. Frank Peacock (2014) conducted a review in Anticoagulation management and bleeding. Target-specific oral anticoagulants (dabigatran, apixaban, rivaroxaban) vs. Traditional anticlotting agents (heparins and warfarin) was evaluated. Target-specific oral anticoagulants require specific institutional protocols for emergency reversal and bleeding management until comprehensive clinical guidelines are developed.
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