Key result
Lower baseline serum adiponectin concentrations were independently associated with an increased risk of developing type 2 diabetes and the metabolic syndrome over 3 years in elderly Koreans.
Why the study?
Do low baseline serum adiponectin concentrations predict the development of type 2 diabetes and metabolic syndrome in elderly Koreans?
Cohort (n=372)
Do low baseline serum adiponectin concentrations predict the development of type 2 diabetes and metabolic syndrome in elderly Koreans?
Reduced serum adiponectin concentrations independently predict the future development of type 2 diabetes and metabolic syndrome in elderly individuals.
Answers are grounded in this paper and cite their sources.
Should not yet guide screening in elderly Koreans; extends adiponectin associations to this group but remains hypothesis-generating.
OBJECTIVE: To determine whether low serum adiponectin concentrations are able to predict the future developments of type 2 diabetes and the metabolic syndrome using the National Cholesterol Education Programme (NCEP) criteria. We also investigated the stability of adiponectin levels and the relationships between baseline adiponectin levels and changes in the parameters related to the metabolic syndrome over a period of 3 years. PATIENTS AND MEASUREMENTS: This prospective cohort study included 372 elderly Koreans who participate in the SWS (South-West Seoul) study, which was conducted in 1999 and 2002 in Seoul, Korea. Fasting and postchallenge 2-h plasma glucose, body mass index (BMI), waist-to-hip ratio (WHR), blood pressure, lipid profiles and serum adiponectin data obtained in 1999 and 2002 were examined. RESULTS: The within-person variation between 1999 and 2002 of serum adiponectin was not significant (P = 0.61). Serum adiponectin was closely correlated with the risks factors of cardiovascular disease (CVD), that is negatively with BMI, WHR, blood pressure, triglyceride and blood glucose levels, and positively with high density lipoprotein (HDL)-cholesterol levels. Subjects with the metabolic syndrome showed lower serum adiponectin concentrations than those without the metabolic syndrome (P < 0.0001). Baseline adiponectin levels were found to be correlated with subsequent changes in WHR, low density lipoprotein (LDL)-cholesterol, fasting and postload 2-h glucose over the 3-year period, after adjusting for baseline values. Multiple logistic regression analysis showed that lower baseline serum adiponectin concentrations were significantly associated with the developments of type 2 diabetes and the metabolic syndrome after adjusting for age, sex, obesity, history of impaired fasting glucose (IFG) or impaired glucose tolerance (IGT), hypertension and dyslipidaemia. CONCLUSIONS: Reduced concentrations of adiponectin were found to be independently associated with increased risk of both type 2 diabetes and the metabolic syndrome in elderly Koreans.
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Choi et al. (2004) conducted a cohort in Type 2 diabetes and metabolic syndrome (n=372). Low serum adiponectin concentrations vs. Higher serum adiponectin concentrations was evaluated on Development of type 2 diabetes and the metabolic syndrome. Lower baseline serum adiponectin concentrations were independently associated with an increased risk of developing type 2 diabetes and the metabolic syndrome over 3 years in elderly Koreans.
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