Key result
The mdx4cv/mTRG2 mouse model with humanized, shortened telomeres most closely approximates the human skeletal and cardiovascular features of Duchenne muscular dystrophy compared to existing models.
Population
Duchenne muscular dystrophy (DMD) mouse models, specifically mdx mice and models with shortened telomeres
Design
Review
Authors
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May enhance DMD cardiomyopathy modeling; leaves open improved translation to patients.
Mdx mice with shortened telomeres may serve as a better preclinical model for studying Duchenne muscular dystrophy cardiomyopathy compared to standard mdx mice.
Yucel et al. (2018) conducted a review in Duchenne muscular dystrophy (DMD). mdx4cv/mTRG2 mouse model vs. Other DMD mouse models was evaluated. The mdx4cv/mTRG2 mouse model with humanized, shortened telomeres most closely approximates the human skeletal and cardiovascular features of Duchenne muscular dystrophy compared to existing models.
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