Key result
Duchenne Muscular Dystrophy patients had significantly lower left ventricular ejection fraction compared to healthy controls (53.9% vs 63%, p<0.001), and those with CMR-documented myocardial inflammation experienced rapid progression to heart failure.
Why the study?
Does myocardial inflammation documented by CMR predict rapid progression to heart failure in patients with Duchenne Muscular Dystrophy?
Population
20 patients with Duchenne Muscular Dystrophy aged 15-18 years, and 20 age-matched healthy volunteers.
Comparison
Evaluation of myocardial inflammation using… vs Age-matched healthy volunteers.
Design
Cohort
Follow-up
2 years
Authors
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CMR-detected myocardial inflammation may flag DMD patients for intensified HF monitoring; leaves open whether anti-inflammatory therapy alters progression.
Cohort (n=40)
No
Does myocardial inflammation documented by CMR predict rapid progression to heart failure in patients with Duchenne Muscular Dystrophy?
Absolute Event Rate: 53.9% vs 63%
p-value: p=<0.001
Myocardial inflammation detected by CMR in patients with Duchenne Muscular Dystrophy is associated with rapid deterioration of left ventricular function and progression to heart failure.
Mavrogeni et al. (2010) conducted a cohort in Duchenne Muscular Dystrophy (n=40). Duchenne Muscular Dystrophy vs. Healthy volunteers was evaluated on Left ventricular ejection fraction (LVEF) (p=<0.001). Duchenne Muscular Dystrophy patients had significantly lower left ventricular ejection fraction compared to healthy controls (53.9% vs 63%, p<0.001), and those with CMR-documented myocardial inflammation experienced rapid progression to heart failure.
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