What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Early pregnancy (n=40). Intervention: Early pregnancy vs. Non-pregnant women. Primary outcome: Increase in ventilation before the ventilatory threshold (L min-1 min-1) (p=<0.001).

What question did this study set out to answer?

To evaluate the physiological and cardiopulmonary response to submaximal exercise testing in women during early pregnancy compared to non-pregnant controls.

November 1, 2020Physiological ReportsOpen Access

The physiological effect of early pregnancy on a woman’s response to a submaximal cardiopulmonary exercise test

Q: What are the key findings of this study?

Early pregnancy was associated with a larger increase in ventilation before the ventilatory threshold (+6.2 vs +3.2 L/min/min; p<0.001) and slower hemodynamic recovery during submaximal exercise.

Q: What question did this study set out to answer?

To evaluate the physiological and cardiopulmonary response to submaximal exercise testing in women during early pregnancy compared to non-pregnant controls.

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Key result

Early pregnancy was associated with a larger increase in ventilation before the ventilatory threshold (+6.2 vs +3.2 L/min/min; p<0.001) and slower hemodynamic recovery during submaximal exercise.

Why the study?

Because pregnancy shares features with physical exercise due to systemic adaptive requirements, this study aimed to assess the physiological response to submaximal CPET in early pregnancy.

Does early pregnancy alter the physiological response to submaximal cardiopulmonary exercise testing in healthy women?

Population

20 healthy pregnant women (<13 weeks gestation) and 20 healthy non-pregnant women

Comparison

Pregnant women vs non-pregnant women

Design

Pilot study

Authors

RBR. BijlErasmus MC JCJérôme CornetteUniversity of Antwerp KHKim van der HamErasmus University Rotterdam

Discussion

Member takes

Implication

Early pregnancy was associated with altered submaximal exercise responses; leaves open effects on CPET interpretation and requires prospective confirmation.

Key Points

To evaluate the physiological and cardiopulmonary response to submaximal exercise testing in women during early pregnancy compared to non-pregnant controls.
Enrolled 20 healthy pregnant women (<13 weeks gestation) and 20 healthy non-pregnant controls.
Conducted a submaximal cardiopulmonary exercise test using stationary cycling up to 70% of estimated maximum heart rate.
Monitored hemodynamic and respiratory variables non-invasively via impedance cardiography and breath-by-breath gas analysis, analyzed using age-adjusted linear regression.
Pregnant women exhibited a greater increase in ventilation before the ventilatory threshold (+6.2 [5.4 to 7.0] vs. +3.2 [2.4 to 3.9] L/min/min; p < 0.001) and lower end-tidal CO2 at the threshold (33 [31 to 34] vs. 36 [34 to 38] mmHg; p = 0.042).
Breathing frequency increased more sharply after the ventilatory threshold in pregnant individuals (+4.6 [2.8 to 6.4] vs. +0.6 [-1.1 to 2.3] breaths/min/min; p = 0.015).
Cardiac output and heart rate responses during cycling were comparable, but pregnant women showed slower 1-minute post-exercise recovery of cardiac output (-3.9 [-5.5 to -2.3] vs. -6.6 [-8.2 to -5.1] L/min/min; p = 0.058) and heart rate (-38 [-47 to -28] vs. -53 [-62 to -44] bpm/min; p = 0.065).

Study Design

Type

Cross-Sectional (n=40)

Structured PICO

Does early pregnancy alter the physiological response to submaximal cardiopulmonary exercise testing in healthy women?

Population

40 healthy women (20 pregnant at <13 weeks gestation and 20 non-pregnant) who underwent submaximal cardiopulmonary exercise testing.

Exposure

Early pregnancy (<13 weeks gestation)

Comparator

Non-pregnant state

Outcome

Physiological response (hemodynamic and respiratory parameters) to submaximal cardiopulmonary exercise testing (CPET) with stationary cycling until 70% of estimated maximum heart rate.surrogate

Main Result

Absolute Event Rate: 6.2% vs 3.2%

p-value: p=<0.001

Early pregnancy is associated with a slower hemodynamic recovery and an increased ventilatory response to submaximal exercise.

Cite This Study

Bijl et al. (2020) conducted a cross-sectional in Early pregnancy (n=40). Early pregnancy vs. Non-pregnant women was evaluated on Increase in ventilation before the ventilatory threshold (L min-1 min-1) (p=<0.001). Early pregnancy was associated with a larger increase in ventilation before the ventilatory threshold (+6.2 vs +3.2 L/min/min; p<0.001) and slower hemodynamic recovery during submaximal exercise.

synapsesocial.com/papers/6a846627f6d812dcfa83dfe2 https://doi.org/10.14814/phy2.14624

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Implication

Early pregnancy was associated with altered submaximal exercise responses; leaves open effects on CPET interpretation and requires prospective confirmation.

The physiological effect of early pregnancy on a woman’s response to a submaximal cardiopulmonary exercise test

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

The physiological effect of early pregnancy on a woman’s response to a submaximal cardiopulmonary exercise test

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider