Key result
Systemic anticoagulation is required during veno-venous extracorporeal membrane oxygenation to prevent thrombosis caused by blood exposure to non-biological surfaces and high shear stress.
Highlights the delicate balance between thrombosis and bleeding risks during veno-venous extracorporeal membrane oxygenation (VV-ECMO) due to blood exposure to non-biological surfaces and high shear stress.
During veno-venous extracorporeal membrane oxygenation (VV-ECMO), a pump drains blood from a large vein, moves it towards a membrane oxygenator, where gas exchange occurs, and then pushes it back into a large vein (1). Blood is thus continuously exposed to non-biological surfaces, including cannulas and membrane oxygenator, and high shear stress, mainly generated by the pump. Platelets and coagulation are activated so that systemic anticoagulation is needed to prevent thrombosis, inside and outside the body.
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Protti et al. (2016) conducted an editorial in Veno-venous extracorporeal membrane oxygenation (VV-ECMO). Systemic anticoagulation was evaluated. Systemic anticoagulation is required during veno-venous extracorporeal membrane oxygenation to prevent thrombosis caused by blood exposure to non-biological surfaces and high shear stress.
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