The study provides new insights into the monomer-dimer equilibrium of daunorubicin in aqueous solutions, differing from previous reports.
Questions prior daunorubicin equilibrium constants; leaves open validation in relevant models before any interpretive or translational use.
The self‐association of daunorubicin in aqueous solution has been examined using visible absorption, fluorescence, and CD measurements. Spectral changes in the concentration range 10 −6 to 1.5 × 10 −3 M have been interpreted in terms of a monomer–dimer equilibrium for daunorubicin. The data have been analyzed using a nonlinear curve‐fitting technique. The results obtained in this study differ markedly from previously published results, and possible reasons for this difference are discussed. The effect of solvent, temperature, and ionic strength on the dimerization process is investigated.
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Stephen R. Martin (1980) studied this question.
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