Papillary thyroid carcinoma (PTC), multinodular goiter (MNG) and autonomous functioning nodule (AFN) have always been considered different from each other, in theft behavior and histopathological features. Generally speaking, an AFN appears ”hot” and the majority of thyroid carcinomas present as a ”cold” nodule on radionuclide scintigraphy. A MNG is usually thought to result from a hyperplastic response of the gland to certain stimulus, showing heterogenous tracer concentration. We report a subclinical hyperthyrotic woman, with thyroid autonomy on Tc-99m scintigraphy, who received hemithyroidectomy. The specimen histologically showed MNG concomitant microcarcinoma and lymphocytic thyroiditis. This unique composition of different thyroid lesions in the same lobe implies certain common mechanisms leading to the pathogenesis of lesions.
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Yang et al. (2011) studied this question.
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