What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Left ventricular diastolic dysfunction in patients undergoing peritoneal dialysis (n=149). Intervention: Epicardial fat thickness vs. Lower epicardial fat thickness / Controls without LVDD. Primary outcome: Presence of left ventricular diastolic dysfunction (LVDD) (OR 2.41, 95% CI 1.43-4.08, p=<0.01).

August 30, 2013Cardiovascular DiabetologyOpen Access

Accumulation of epicardial fat rather than visceral fat is an independent risk factor for left ventricular diastolic dysfunction in patients undergoing peritoneal dialysis

Q: What are the key findings of this study?

Epicardial fat thickness was a powerful independent determinant of left ventricular diastolic dysfunction in patients undergoing peritoneal dialysis (OR 2.41).

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Key result

Epicardial fat thickness was a powerful independent determinant of left ventricular diastolic dysfunction in patients undergoing peritoneal dialysis (OR 2.41).

Why the study?

Is epicardial fat thickness associated with left ventricular diastolic dysfunction in patients undergoing peritoneal dialysis?

Population

149 patients with preserved left ventricular systolic function who were undergoing peritoneal dialysis (PD)

Comparison

Epicardial fat thickness measured by… vs Patients without left ventricular diastolic…

Design

Cross-sectional

Authors

HLHeng‐Hsu Lin JLJen-Kuang Lee CYChung-Yi Yang

Discussion

Member takes

Overview

May flag diastolic dysfunction risk in peritoneal dialysis; leaves open causality and need for longitudinal confirmation.

Study Design

Type

Cross-Sectional (n=149)

Multicenter

Structured PICO

Is epicardial fat thickness associated with left ventricular diastolic dysfunction in patients undergoing peritoneal dialysis?

Population

149 Taiwanese patients undergoing peritoneal dialysis for more than 6 months with preserved left ventricular systolic function, evaluated cross-sectionally for left ventricular diastolic dysfunction.

Exposure

Epicardial fat (EpF) thickness measured by echocardiography

Comparator

Patients without left ventricular diastolic dysfunction (controls)

Outcome

Left ventricular diastolic dysfunction (LVDD) diagnosed according to European Society of Cardiology guidelinessurrogate

Main Result

Odds Ratio: 2.41 (95% CI 1.43–4.08)

p-value: p=<0.01

Epicardial fat thickness is independently associated with left ventricular diastolic dysfunction in patients undergoing peritoneal dialysis, suggesting a potential pathogenic role.

Limitations

Cross-sectional design limits the ability to infer longitudinal or causal relationships.
The study population consisted entirely of Taiwanese patients, which may limit generalizability to other populations.
The effects of LVDD and epicardial fat thickness on long-term outcomes warrant further investigation.

Cite This Study

Lin et al. (2013) conducted a cross-sectional in Left ventricular diastolic dysfunction in patients undergoing peritoneal dialysis (n=149). Epicardial fat thickness vs. Lower epicardial fat thickness / Controls without LVDD was evaluated on Presence of left ventricular diastolic dysfunction (LVDD) (OR 2.41, 95% CI 1.43-4.08, p=<0.01). Epicardial fat thickness was a powerful independent determinant of left ventricular diastolic dysfunction in patients undergoing peritoneal dialysis (OR 2.41).

synapsesocial.com/papers/6a8469c3d87e21f83cb29dff https://doi.org/10.1186/1475-2840-12-127

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August 30, 2013Cardiovascular DiabetologyOpen Access

Accumulation of epicardial fat rather than visceral fat is an independent risk factor for left ventricular diastolic dysfunction in patients undergoing peritoneal dialysis

View Full Paper

Ask AI

Bookmark

Key result

Epicardial fat thickness was a powerful independent determinant of left ventricular diastolic dysfunction in patients undergoing peritoneal dialysis (OR 2.41).

Why the study?

Is epicardial fat thickness associated with left ventricular diastolic dysfunction in patients undergoing peritoneal dialysis?

Population

149 patients with preserved left ventricular systolic function who were undergoing peritoneal dialysis (PD)

Comparison

Epicardial fat thickness measured by… vs Patients without left ventricular diastolic…

Design

Cross-sectional

Authors

HLHeng‐Hsu Lin JLJen-Kuang Lee CYChung-Yi Yang

Discussion

Member takes

Overview

May flag diastolic dysfunction risk in peritoneal dialysis; leaves open causality and need for longitudinal confirmation.

Study Design

Type

Cross-Sectional (n=149)

Multicenter

Structured PICO

Is epicardial fat thickness associated with left ventricular diastolic dysfunction in patients undergoing peritoneal dialysis?

Population

149 Taiwanese patients undergoing peritoneal dialysis for more than 6 months with preserved left ventricular systolic function, evaluated cross-sectionally for left ventricular diastolic dysfunction.

Exposure

Epicardial fat (EpF) thickness measured by echocardiography

Comparator

Patients without left ventricular diastolic dysfunction (controls)

Outcome

Left ventricular diastolic dysfunction (LVDD) diagnosed according to European Society of Cardiology guidelinessurrogate

Main Result

Odds Ratio: 2.41 (95% CI 1.43–4.08)

p-value: p=<0.01

Epicardial fat thickness is independently associated with left ventricular diastolic dysfunction in patients undergoing peritoneal dialysis, suggesting a potential pathogenic role.

Limitations

Cross-sectional design limits the ability to infer longitudinal or causal relationships.
The study population consisted entirely of Taiwanese patients, which may limit generalizability to other populations.
The effects of LVDD and epicardial fat thickness on long-term outcomes warrant further investigation.

Cite This Study

synapsesocial.com/papers/6a8469c3d87e21f83cb29dff https://doi.org/10.1186/1475-2840-12-127

Also Consider

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