Key result
Subclinical hypothyroidism was associated with significantly lower aortic velocity propagation (43.7 vs 62.6; p<0.001) and higher carotid intima-media thickness compared to euthyroid controls.
Why the study?
Subclinical hypothyroidism is linked to endothelial dysfunction and atherosclerotic cardiovascular disease, and markers like AVP, EFT, and CIMT may provide additional diagnostic information.
Are aortic velocity propagation, epicardial fat thickness, and carotid intima-media thickness altered in patients with subclinical hypothyroidism compared to euthyroid individuals?
Cross-Sectional (n=123)
Are aortic velocity propagation, epicardial fat thickness, and carotid intima-media thickness altered in patients with subclinical hypothyroidism compared to euthyroid individuals?
Absolute Event Rate: 43.7% vs 62.6%
p-value: p=<0.001
Subclinical hypothyroidism is associated with increased carotid intima-media thickness and decreased aortic velocity propagation, suggesting early atherosclerotic and hemodynamic changes.
May signal early vascular changes in subclinical hypothyroidism; hypothesis-generating and should not yet change practice.
Subclinical hypothyroidism (SH) is associated with hemodynamic and metabolic abnormalities that cause endothelial dysfunction and atherosclerotic cardiovascular diseases. Aortic velocity propagation (AVP), epicardial fat thickness (EFT), and carotid intima-media thickness (CIMT) may provide additional information in SH patients. This study aimed to evaluate thyroid stimulating hormone (TSH), AVP, EFT, and CIMT in SH patients, and determine the associations among these parameters. Eighty patients with SH and 43 euthyroid (EU) individuals were enrolled. Blood samples were collected to measure laboratory parameters. Patients were divided into two groups based on their TSH values (TSH ≥10 or TSH <10 mIU/L). AVP, EFT, and CIMT were measured and compared between the study groups. A multivariate linear regression model was used for analysis of the independent predictors of AVP (beta = –0.298; 95% confidence interval = –0.946 to –0.287; p < 0.001). AVP was significantly lower in SH patients than the control group (43.7 ± 12.5 and 62.6 ± 13.8, respectively; p < 0.001). EFT values were similar between the SH and control groups (0.7 ± 0.3 and 0.6 ± 0.2, respectively; p = 0.10). SH patients had higher CIMT values than the control group (0.8 ± 0.3 and 0.5 ± 0.2, respectively; p < 0.001). In the multivariate linear analysis, TSH was an independent predictor of AVP. AVP was lower and CIMT was higher in SH patients compared to EU individuals. The increased CIMT and decreased AVP levels were significantly associated with TSH levels in SH patients.
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Asoğlu et al. (2021) conducted a cross-sectional in Subclinical hypothyroidism (n=123). Subclinical hypothyroidism vs. Euthyroid individuals was evaluated on Aortic velocity propagation (AVP) (p=<0.001). Subclinical hypothyroidism was associated with significantly lower aortic velocity propagation (43.7 vs 62.6; p<0.001) and higher carotid intima-media thickness compared to euthyroid controls.
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