Key result
Subclinical hypothyroidism is linked to ~29% greater epicardial adipose tissue thickness vs. matched controls.
Why the study?
Is newly diagnosed subclinical hypothyroidism associated with increased epicardial adipose tissue thickness compared with euthyroid controls?
Cross-Sectional (n=85)
Blinded echocardiographer
No
Is newly diagnosed subclinical hypothyroidism associated with increased epicardial adipose tissue thickness compared with euthyroid controls?
Answers are grounded in this paper and cite their sources.
Newly diagnosed subclinical hypothyroidism is associated with increased echocardiographic epicardial adipose tissue thickness that correlates positively with TSH levels, suggesting a potential mechanism linking subclinical thyroid dysfunction to elevated cardiovascular risk.
OBJECTIVE: To investigate whether or not patients with subclinical hypothyroidism (SH) have increased epicardial adipose tissue (EAT). SUBJECTS AND METHODS: Sixty-one patients with newly diagnosed SH and without any known cardiovascular disease were enrolled. Twenty-four subjects matched for age, gender and body mass index without any thyroid dysfunctions were included as a control group. The EAT was measured by echocardiography and thyroid functions were assessed by routine blood examination. RESULTS: Patients with SH had higher EAT values than control subjects (3.6 ± 0.9 vs. 2.8 ± 1.4, p = 0.005). Also, SH patients with thyroid-stimulating hormone (TSH) ≥10 mU/l had higher EAT than those with SH with TSH <10 mU/l and control subjects (p = 0.013). In addition, while there was significant correlation between EAT and TSH (r = 0.31, p = 0.014) in patients with SH, there was no significant relation between EAT and TSH in normal subjects (r = 0.09, p = 0.64). CONCLUSIONS: There was a higher level of EAT in patients with SH compared with normal subjects and a significant correlation between EAT and TSH was found.
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Korkmaz et al. (2012) conducted a cross-sectional in Subclinical hypothyroidism (n=85). Newly diagnosed subclinical hypothyroidism vs. Subjects matched for age, gender, and body mass index without any thyroid dysfunctions was evaluated on Epicardial adipose tissue (EAT) thickness measured by transthoracic echocardiography (p=0.005). Patients with newly diagnosed subclinical hypothyroidism had higher echocardiographic epicardial adipose tissue thickness than matched controls.
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