A synthesis of ( R )‐muscone ( 1 ), a valuable musk odorant, is presented. The stereogenic center of muscone was introduced from methyl ( R )‐5‐bromo‐4‐methylpentanoate ( 5 ), a chiral pool molecule developed in our group, and the macrocyclic ring was prepared by ring‐closing metathesis (RCM) reaction.
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Shen et al. (2015) studied this question.
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