A new synthesis of (−)‐( R )‐muscone (( R )‐ 1 ) by means of enantioselective protonation of a bicyclic ketone enolate as the key step (see 6 →( S )‐ 4 in Scheme 2 ) is presented. The C 15 macrocyclic system is obtained by ozonolysis ( Scheme 7 ).
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Fehr et al. (2004) studied this question.
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