Key result
Both regional and diet-induced increases in atherogenic risk were associated with significantly thinner glycocalyces and greater intima-to-media ratios (P<0.05).
p-value: p=<0.05
Both regional and diet-induced increases in atherogenic risk are associated with smaller glycocalyx dimensions and greater intima-to-media ratios in murine carotid arteries, suggesting increased vulnerability to atherosclerosis.
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Glycocalyx thinning may mark early atherogenic vulnerability in mice; hypothesis-generating for human studies.
Berg et al. (2005) studied Atherosclerosis risk. Atherogenic diet and high-risk arterial region vs. Normal diet and low-risk arterial region was evaluated on Glycocalyx dimension and intima-to-media ratios (IMR) (p=<0.05). Both regional and diet-induced increases in atherogenic risk were associated with significantly thinner glycocalyces and greater intima-to-media ratios (P<0.05).
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