What question did this study set out to answer?

To explore how plaque distribution correlates with flow velocity profiles and wall shear stress in human carotid bifurcations.

October 1, 1983Circulation Research

Carotid bifurcation atherosclerosis. Quantitative correlation of plaque localization with flow velocity profiles and wall shear stress.

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Population

12 adult human carotid bifurcations obtained at autopsy with nonstenosing, asymptomatic intimal plaques

Design

Preclinical

Authors

CZC K ZarinsStanford Medicine DGD. P. GiddensGeorgia Institute of Technology BBB. K. BharadvajCalifornia State University, Long Beach

Discussion

Member takes

Implication

Animal evidence links low shear stress to intimal thickening; leaves open translation to human atherosclerosis prevention.

Key Points

To explore how plaque distribution correlates with flow velocity profiles and wall shear stress in human carotid bifurcations.
Analyzed 12 postmortem carotid bifurcation specimens at autopsy for plaque distribution.
Measured flow velocity profiles and shear stress using scale models under various Reynolds numbers.
Determined intimal thickness at multiple sampling sites and utilized laser-Doppler anemometry for flow analysis.
Intimal thickening was greatest at the carotid sinus, particularly eccentric to the flow divider.
Wall shear stress along the inner wall ranged from 31 to 600 dynes/cm2 while the outer wall showed 0 to -6 dynes/cm2.
Regions of high shear stress remain unthickened, indicating that low shear stress contributes to atherosclerosis.

Structured PICO

Population

12 adult human carotid bifurcations obtained at autopsy with nonstenosing, asymptomatic intimal plaques

Outcome

Correlation of intimal thickness with flow velocity profiles and wall shear stresssurrogate

Intimal thickening and atherosclerosis in the human carotid bifurcation develop largely in regions of relatively low wall shear stress and flow separation, while regions of moderate to high shear stress are relatively spared.

Cite This Study

Zarins et al. (1983) studied this question.

synapsesocial.com/papers/69d83efc8cb8f39931ae29b9 https://doi.org/10.1161/01.res.53.4.502

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Carotid bifurcation atherosclerosis. Quantitative correlation of plaque localization with flow velocity profiles and wall shear stress.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Carotid bifurcation atherosclerosis. Quantitative correlation of plaque localization with flow velocity profiles and wall shear stress.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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