Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 23, 2012Journal of Mechanics in Medicine and BiologyOpen Access

A high level of compression occurs at the stenotic apex, and wall shear stress and deformation are significantly affected by the degree of stenosis.

View Full Paper
Ask AI
Bookmark
Share

Population

Three-dimensional atherosclerotic carotid bifurcation model (idealistic geometries)

Design

Preclinical

Authors

KWKelvin K. L. WongPTPongpat ThavornpattanapongSCSherman C.P. Cheung

Discussion

Loading...

Member takes

Overview

Hypothesis-generating for biomechanical drivers of carotid plaque; human validation required before clinical consideration.

Structured PICO

P
Population
Three-dimensional atherosclerotic carotid bifurcation model (idealistic geometries)
I
Intervention
Fluid-structure interaction (FSI) simulation of pulsatile flow
O
Outcome
Fluid and structural properties including wall shear stress, stenotic compression, and deformationsurrogate

Computational fluid-structure interaction modeling demonstrates that high compression at the stenotic apex and altered wall shear stress may drive plaque progression in carotid atherosclerosis.

Cite This Study

Wong et al. (2012) studied this question.

synapsesocial.com/papers/6a8d1546b6a5e72a852fe2bfhttps://doi.org/10.1142/s0219519413500012
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Numerical simulation of blood flow in 3D CT-based healthy and atherosclerosis carotid artery bifurcation models to compare the hemodynamics and biomechanics using FSI method under realistic boundary conditions2025 · 2 citations
  2. 2Fluid-structure interaction study of hemodynamics and its biomechanical influence on carotid artery atherosclerotic plaque deposits2023 · 34 citations
  3. 3Fluid-structure interaction analysis of stenosed carotid arteries: Evaluating hemodynamics, plaque vulnerability, and endothelial stimulation potential2025 · 4 citations
  4. 4Atherosclerosis and flow in carotid arteries with authentic geometries2002 · 29 citations
  5. 5The role of fluid dynamics in plaque excavation and rupture in the human carotid bifurcation: a computational study2009 · 7 citations