January 1, 2009International Journal of Experimental and Computational Biomechanics

The role of fluid dynamics in plaque excavation and rupture in the human carotid bifurcation: a computational study

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Population

3D computational fluid dynamics model of the human carotid bifurcation based on computerised tomography…

Design

Preclinical

Authors

SLScott Lovald JHJuan C. Heinrich TKTariq Khraishi

Discussion

Member takes

Overview

May inform carotid stenosis hemodynamics models; leaves open clinical correlation with plaque rupture pending human validation.

Structured PICO

Population

3D computational fluid dynamics model of the human carotid bifurcation based on computerised tomography scans of a patient with moderate plaque stenosis

Intervention

Simulated atherosclerotic stenosis of varying degrees (30%, 50%, 70%, 80%)

Outcome

Hemodynamic parameters including blood flow, pressure, wall shear stress, and the product of pressure and wall shear stress gradientsurrogate

Computational fluid dynamics modeling demonstrates that increasing carotid stenosis exponentially increases peak wall shear stress, which may correlate with clinical plaque excavation and rupture.

Cite This Study

Lovald et al. (2009) studied this question.

synapsesocial.com/papers/6a8ce3c7551dbf60cd71b8ea https://doi.org/10.1504/ijecb.2009.022860

View Full Paper

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January 1, 2009International Journal of Experimental and Computational Biomechanics

The role of fluid dynamics in plaque excavation and rupture in the human carotid bifurcation: a computational study

View Full Paper

Ask AI

Bookmark

Population

3D computational fluid dynamics model of the human carotid bifurcation based on computerised tomography…

Design

Preclinical

Authors

SLScott Lovald JHJuan C. Heinrich TKTariq Khraishi

Discussion

Member takes

Overview

May inform carotid stenosis hemodynamics models; leaves open clinical correlation with plaque rupture pending human validation.

Structured PICO

Population

3D computational fluid dynamics model of the human carotid bifurcation based on computerised tomography scans of a patient with moderate plaque stenosis

Intervention

Simulated atherosclerotic stenosis of varying degrees (30%, 50%, 70%, 80%)

Outcome

Hemodynamic parameters including blood flow, pressure, wall shear stress, and the product of pressure and wall shear stress gradientsurrogate

Computational fluid dynamics modeling demonstrates that increasing carotid stenosis exponentially increases peak wall shear stress, which may correlate with clinical plaque excavation and rupture.

Cite This Study

Lovald et al. (2009) studied this question.

synapsesocial.com/papers/6a8ce3c7551dbf60cd71b8ea https://doi.org/10.1504/ijecb.2009.022860

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