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June 23, 2025Results in EngineeringOpen Access

Fluid-structure interaction analysis of stenosed carotid arteries: Evaluating hemodynamics, plaque vulnerability, and endothelial stimulation potential

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Why the study?

Atherosclerosis is a serious cardiovascular disease due to its asymptomatic behavior at its initial stage, motivating investigation of hemodynamics and arterial wall-blood flow interactions in stenosed carotid arteries.

Population

Idealized stenosed carotid artery with approximately 20% stenosis

Comparison

Fluid-Structure Interaction approach vs rigid wall assumption

Design

Computational simulation study

Authors

NKNitesh KumarHGH GirishAGA. Ganesha

Discussion

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Overview

These simulation findings should not change practice for mild carotid disease; they leave open whether FSI metrics can refine plaque-vulnerability assessment.

Structured PICO

P
Population
Idealized computational model of a stenosed carotid artery with approximately 20% stenosis at the sinus region
I
Intervention
Fluid-Structure Interaction (FSI) analysis using a non-Newtonian Carreau-Yasuda model for blood flow and linear isotropic material for the arterial wall
C
Comparator
Rigid wall assumption
O
Outcome
Hemodynamic parameters including velocity, wall shear stress (WSS), oscillatory shear index (OSI), relative residence time (RRT), endothelial stimulation potential (ESP), vorticity, and helicitysurrogate

Fluid-structure interaction modeling of a stenosed carotid artery demonstrates significant hemodynamic alterations, such as elevated oscillatory shear index and reduced wall shear stress, which may accelerate atherosclerosis progression.

Limitations

  • Use of idealized geometry rather than patient-specific geometries
  • Use of linear isotropic material for arterial wall rather than hyperelastic properties

Cite This Study

Kumar et al. (2025) studied this question.

synapsesocial.com/papers/6a7fe3b8ec1eb8bfa53a968chttps://doi.org/10.1016/j.rineng.2025.105943
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Fluid-structure interaction study of hemodynamics and its biomechanical influence on carotid artery atherosclerotic plaque deposits2023 · 34 citations
  2. 2Numerical simulation of blood flow in 3D CT-based healthy and atherosclerosis carotid artery bifurcation models to compare the hemodynamics and biomechanics using FSI method under realistic boundary conditions2025 · 2 citations
  3. 3Fluid structure interaction analysis to stratify the behavior of different atheromatous carotid plaques2022
  4. 4Hemodynamic Study of Blood Flow in the Carotid Artery With a Focus on Carotid Sinus Using Fluid-Structure Interaction2021 · 23 citations
  5. 5BIOMECHANICAL INVESTIGATION OF PULSATILE FLOW IN A THREE-DIMENSIONAL ATHEROSCLEROTIC CAROTID BIFURCATION MODEL2012 · 35 citations