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January 1, 2015Medical Science Monitor

Maximum von Mises stress was significantly higher in vulnerable plaques compared to stable plaques (P<0.001) and in plaques with fibrous cap defects (P=0.001).

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Why the study?

Can subject-specific fluid-structure interaction models based on MRI accurately assess the hemodynamics and vulnerability of carotid atherosclerotic plaques?

Population

52 patients with carotid atherosclerotic plaques and 12 healthy participants

Comparison

Subject-specific fluid-structure interaction… vs One-way FSI models and healthy controls

Design

Other, 19 randomly selected models for comparison of one-way vs fully-coupled…

Authors

XTXiaojuan TaoSoochow UniversityPGPeiyi GaoCapital UniversityLJLina JingChinese Academy of Medical Sciences & Peking Union Medical College

Discussion

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Member takes

Overview

Higher stress may flag vulnerable carotid plaques on MRI models; leaves open whether fluid-structure interaction improves noninvasive risk stratification.

Structured PICO

Can subject-specific fluid-structure interaction models based on MRI accurately assess the hemodynamics and vulnerability of carotid atherosclerotic plaques?

P
Population
52 patients with carotid atherosclerotic plaques (yielding 86 models) and 12 healthy participants (yielding 14 normal carotid models)
I
Intervention
Subject-specific fluid-structure interaction (FSI) models based on MRI (fully-coupled FSI)
C
Comparator
One-way FSI models and healthy controls
O
Outcome
Maximum von Mises stress, minimum pressure, and flow velocity values at the most stenotic site or carotid bifurcationsurrogate

MRI-based fluid-structure interaction modeling can noninvasively assess plaque hemodynamics and identify vulnerable carotid plaques based on mechanical stress.

Cite This Study

Tao et al. (2015) studied this question.

synapsesocial.com/papers/6a8bb7b2f71b672e3df48fd4https://doi.org/10.12659/msm.895137
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Fluid-structure interaction study of hemodynamics and its biomechanical influence on carotid artery atherosclerotic plaque deposits2023 · 34 citations
  2. 2Fluid-structure interaction analysis of stenosed carotid arteries: Evaluating hemodynamics, plaque vulnerability, and endothelial stimulation potential2025 · 4 citations
  3. 3A Computational Fluid–Structure Interaction Study for Carotids With Different Atherosclerotic Plaques2021 · 25 citations
  4. 4Numerical simulation of blood flow in 3D CT-based healthy and atherosclerosis carotid artery bifurcation models to compare the hemodynamics and biomechanics using FSI method under realistic boundary conditions2025 · 2 citations
  5. 5Fluid structure interaction analysis to stratify the behavior of different atheromatous carotid plaques2022