Key result
Lipidic carotid plaques absorbed significantly more elastic energy (2320 J/m3) during systole compared to fibrous (408 J/m3) and calcific plaques (99 J/m3), indicating greater vulnerability.
Why the study?
In asymptomatic carotid stenosis, different plaque types (lipidic, fibrous, and calcific) may have different hemodynamic and structural behaviors.
Does plaque composition (lipidic, fibrous, calcific) influence hemodynamic and structural behaviors in asymptomatic carotid stenosis?
Observational (n=15)
Does plaque composition (lipidic, fibrous, calcific) influence hemodynamic and structural behaviors in asymptomatic carotid stenosis?
Computational fluid structure interaction analysis reveals that lipidic carotid plaques absorb significantly more elastic energy and experience higher internal stresses compared to fibrous or calcific plaques, providing a biomechanical basis for their increased vulnerability.
Answers are grounded in this paper and cite their sources.
Lipidic plaques may signal higher rupture risk in asymptomatic carotid stenosis; hypothesis-generating for composition-based risk models.
BACKGROUND: In asymptomatic carotid stenosis (ACS), different plaque types, i.e. lipidic (LP), fibrous (FP), and calcific (CP), could have different hemodynamic and structural behaviors. METHODS: Different carotid plaques, reconstructed from medical imaging of ACS >70%, were analyzed by computing fluid structure interaction (FSI), modeling the spatial distribution of wall shear stresses (WSS), plaque displacements (D), von Mises stresses (VMS), and absorbed elastic energy (AEE) together with their maximum-in-space values at the systole (WSS<inf>syst</inf>, D<inf>syst</inf>, VMS<inf>syst</inf> and AEE<inf>syst</inf>). RESULTS: (2240%), (P<0.01, P<0.01, and P<0.01, respectively). CONCLUSIONS: Depending upon their nature, plaques store different deformations and inner distributions of forces, thus potentially influencing their vulnerability.
No takes yet. Share an insight, caveat, or question.
Domanin et al. (2022) conducted an observational in Asymptomatic carotid stenosis (n=15). Lipidic plaque morphology vs. Calcific plaque morphology was evaluated on Systolic maximum-in-space Absorbed Elastic Energy (AEEsyst) in J/m3 (p=<0.01). Lipidic carotid plaques absorbed significantly more elastic energy (2320 J/m3) during systole compared to fibrous (408 J/m3) and calcific plaques (99 J/m3), indicating greater vulnerability.
Synapse has enriched 10 related papers. Consider them for comparative context: