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May 1, 2002Biorheology

Atherosclerosis and flow in carotid arteries with authentic geometries

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Population

31 post mortem carotid bifurcations

Design

Preclinical

Authors

LGLeonid GoubergritsKAK. AffeldJFJosé Emilio Fernández-Britto

Discussion

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Overview

Animal carotid CFD methodology correlates flow with wall changes; leaves open human translation and clinical utility.

Structured PICO

P
Population
31 post mortem carotid bifurcations
I
Intervention
Computational fluid dynamics modeling (FLUENT) based on individual vessel geometry
O
Outcome
Comparison of anatomical shape and flow parameters (velocity, pressure, wall shear stress) with the distribution and level of wall alterationssurrogate

Computational fluid dynamics modeling of authentic post-mortem carotid geometries enables detailed correlation between flow parameters like wall shear stress and atherosclerotic lesion distribution.

Cite This Study

Goubergrits et al. (2002) studied this question.

synapsesocial.com/papers/6a929778854a33db2d4659fahttps://doi.org/10.1177/0006355x2002039003004033
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1INVESTIGATION OF GEOMETRY AND ATHEROSCLEROSIS IN THE HUMAN CAROTID BIFURCATIONS2003 · 9 citations
  2. 2Numerical flow studies in human carotid artery bifurcations: basic discussion of the geometric factor in atherogenesis1990 · 122 citations
  3. 3BIOMECHANICAL INVESTIGATION OF PULSATILE FLOW IN A THREE-DIMENSIONAL ATHEROSCLEROTIC CAROTID BIFURCATION MODEL2012 · 35 citations
  4. 4Numerical Study of Blood Flow Through Carotid Bifurcation1995
  5. 5Influence of Altered Pressures on Flow Dynamics in Carotid Bifurcation System Using Numerical Methods2022 · 16 citations