Key result
NP-59 scintigraphy always showed bilateral adrenal uptake in PPNAD patients, and asymmetrical uptake correlated with the presence of macronodules at pathological analysis (P = .03).
Population
17 patients with ACTH-independent Cushing's syndrome due to primary pigmented nodular adrenocortical disease.
Design
Case_series
Authors
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May support NP-59 for bilateral confirmation in suspected PPNAD when CT is inconclusive; leaves open validation beyond case reports.
Observational (n=17)
p-value: p=.03
NP-59 scintigraphy consistently demonstrates bilateral adrenal uptake in PPNAD, confirming the bilateral nature of the disease even when CT imaging is non-specific.
Vezzosi et al. (2015) conducted an observational in Cushing's syndrome due to primary pigmented nodular adrenocortical disease (PPNAD) (n=17). NP-59 scintigraphy and standard adrenal CT scan was evaluated on Correlation of asymmetrical adrenal radiocholesterol uptake with the presence of macronodules at pathological analysis (p=.03). NP-59 scintigraphy always showed bilateral adrenal uptake in PPNAD patients, and asymmetrical uptake correlated with the presence of macronodules at pathological analysis (P = .03).
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