Key result
Supplementation with recombined BDNF protein increased survival and improved cardiac function in rats with sepsis by reducing oxidative stress and apoptosis via the eNOS/NO pathway.
Why the study?
Does recombined BDNF protein improve survival and cardiac function in rats with sepsis-induced myocardial dysfunction?
Does recombined BDNF protein improve survival and cardiac function in rats with sepsis-induced myocardial dysfunction?
BDNF protects against sepsis-induced myocardial dysfunction by reducing oxidative stress and apoptosis through the activation of the eNOS/NO pathway in a rat model.
Sepsis-induced myocardial dysfunction increases mortality in sepsis, yet the underlying mechanism is unclear. Brain-derived neurotrophic factor (BDNF) has been found to enhance cardiomyocyte function, but whether BDNF has a beneficial effect against septic myocardial dysfunction is unknown. Septic shock was induced by cecal ligation and puncture (CLP). BDNF was expressed in primary cardiomyocytes, and its expression was significantly reduced after sepsis. In rats with sepsis, a sharp decline in survival was observed after CLP, with significantly reduced cardiac BDNF expression, enhanced myocardial fibrosis, elevated oxidative stress, increased myocardial apoptosis, and decreased endothelial nitric oxide (NO) synthase (eNOS) and NO. Supplementation with recombined BDNF protein (rhBDNF) enhanced myocardial BDNF and increased survival rate with improved cardiac function, reduced oxidative stress, and myocardial apoptosis, which were associated with increased eNOS expression, NO production, and Trk-B, a BDNF receptor. Pretreatment with NOS inhibitor, N (omega)-nitro-L-arginine methyl ester, abolished the abovementioned BDNF cardioprotective effects without affecting BDNF and Trk-B. It is concluded that BDNF protects the heart against septic cardiac dysfunction by reducing oxidative stress and apoptosis via Trk-B, and it does so through activation of eNOS/NO pathway. These findings provide a new treatment strategy for sepsis-induced myocardial dysfunction.
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Zeng et al. (2017) studied Sepsis-induced myocardial dysfunction. Recombined BDNF protein (rhBDNF) vs. No rhBDNF / NOS inhibitor was evaluated on Survival rate and cardiac function. Supplementation with recombined BDNF protein increased survival and improved cardiac function in rats with sepsis by reducing oxidative stress and apoptosis via the eNOS/NO pathway.
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