October 1, 1984Avian PathologyOpen Access

Activating effects of interferons, lymphokines and viruses on cultured chicken macrophages1

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Population

Cultured chicken bone-marrow-derived and blood monocyte-derived macrophages

Design

Preclinical

Authors

VVV. VonBülow HWH. WeilerMcGill University AKA. Klasen

Discussion

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Implication

Endogenous IFN mediates viral macrophage activation in chickens; leaves open translation to mammalian antiviral research.

Structured PICO

Population

Cultured chicken bone-marrow-derived and blood monocyte-derived macrophages

Intervention

Crude lymphokine preparations from ConA-stimulated chicken spleen or thymus cell cultures; virus-induced interferons (IFN) from cultured chicken embryo fibroblasts or macrophages; inactivated reovirus or live infectious bursal disease virus (IBDV)

Outcome

Macrophage activity (expressed by cytostatic effects against lymphoblastoid target cells, and morphological changes such as enhanced spreading)surrogate

This preclinical study demonstrates that chicken macrophages can be activated by lymphokines, interferons, and viruses, with virus-induced activation likely mediated by endogenous interferon.

Cite This Study

VonBülow et al. (1984) studied this question.

synapsesocial.com/papers/6a84738352e6a46b6a68cb5e https://doi.org/10.1080/03079458408418561

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Activating effects of interferons, lymphokines and viruses on cultured chicken macrophages1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Activating effects of interferons, lymphokines and viruses on cultured chicken macrophages1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider