A randomized double‐blind study with placebo control revealed that single large intravenous doses of methylprednisolone sodium succinate produced no serious systemic effects. The effects of a dose of 30 mg. per kilogram given over a 10 minute period were studied. A battery of tests given before, during, and after administration indicated that the physiologic changes are similar in kind and degree to those after oral administration. An ACTH stimulation test suggested that the ability of the adrenal gland to respond is preserved after the single large doses. On the basis of this study it was concluded that, when indicated, doses of up to 30 mg. per kilogram of methylprednisolone sodium succinate were safe for use.
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Novak et al. (1970) studied this question.