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January 1, 2011Journal of Gastroenterology and Hepatology

Nonalcoholic fatty liver in Asia: Firmly entrenched and rapidly gaining ground

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Key result

Nonalcoholic fatty liver disease affects at least 10% of the general population in Asia and is increasingly associated with metabolic syndrome, diabetes, and advanced hepatic fibrosis.

Population

General population in Asia with or at risk of nonalcoholic fatty liver disease (NAFLD)

Design

Review

Authors

SCShivakumar ChitturiCanberra HospitalVWVincent Wai‐Sun WongRutgers, The State University of New JerseyGFGeoff FarrellAustralian National University

Discussion

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Implication

Raises awareness of NAFLD in Asian metabolic patients; leaves open optimal screening and interventions pending prospective trials.

Structured PICO

P
Population
General population in Asia with or at risk of nonalcoholic fatty liver disease (NAFLD)

NAFLD is an increasingly prevalent chronic liver disorder in Asia, closely linked to metabolic syndrome and requiring lifestyle interventions for management.

Limitations

  • Studies on genetic polymorphisms involving adipose distribution, insulin signalling, adipokine responses, and hepatic fibrosis have been underpowered.
  • Further refinements in transient elastography technique are necessary for obese individuals.

Cite This Study

Chitturi et al. (2011) conducted a review in Nonalcoholic fatty liver disease (NAFLD). Nonalcoholic fatty liver disease affects at least 10% of the general population in Asia and is increasingly associated with metabolic syndrome, diabetes, and advanced hepatic fibrosis.

synapsesocial.com/papers/6a84764f002ab1506fb2b85ehttps://doi.org/10.1111/j.1440-1746.2010.06548.x
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