Key result
Treatment with micro laryngoscopy and laser excision followed by R-CHOP and HD-MTX chemotherapy resulted in complete resolution of the primary laryngeal diffuse large B-cell lymphoma with a relapse-free follow-up.
Why the study?
Primary Laryngeal Lymphoma is a rare hematological and laryngeal malignancy requiring chemo-radiotherapy as first-line treatment, with fewer than 100 cases reported in the literature.
Case Report (n=1)
No
Primary laryngeal lymphoma is a rare cause of voice hoarseness that requires a high index of suspicion and is treated primarily with chemo-radiotherapy rather than surgery alone.
May support combined excision and chemotherapy in rare laryngeal lymphoma; hypothesis-generating from single Level 5 case.
Primary Laryngeal Lymphoma is rare both as a hematological and as a laryngeal malignancy. Unlike squamous cell carcinomas, lymphomas require chemo-radiotherapy as 1st-line treatment. A 67-year-old lady presented with voice hoarseness, dyspnea and dysphagia for solids. An otherwise unremarkable physical showed "hot-potato like" voice. Labs were normal, while laryngoscopy and CT revealed an epiglottic mass, which was resected. Biopsy results showed DLBCL. The patient then underwent chemotherapy with complete success. Voice hoarseness has a vast differential diagnosis depending on its character and complementary symptoms. Less than a 100 cases of Primary Laryngeal Lymphoma have been reported in the literature, proving the rarity of this clinical entity.
No takes yet. Share an insight, caveat, or question.
Anatoli Pataridou (2021) conducted a case report in Primary Laryngeal Lymphoma (Diffuse Large B-Cell Lymphoma) (n=1). Micro laryngoscopy with laser CO2 excision followed by R-CHOP and HD-MTX chemotherapy was evaluated on Tumor resolution and relapse-free survival. Treatment with micro laryngoscopy and laser excision followed by R-CHOP and HD-MTX chemotherapy resulted in complete resolution of the primary laryngeal diffuse large B-cell lymphoma with a relapse-free follow-up.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: