Key result
Agents that specifically inhibit BK channel activity, including paxilline and lolitrem B, slowed heart rate in conscious wild-type mice by 30% and 42%, respectively.
Why the study?
Does inhibition of BK channels reduce heart rate in rodents?
Population
Wild-type mice, BK channel knock-out mice aged 2-24 months, and isolated perfused Sprague Dawley rat hearts…
Comparison
BK channel inhibitors including paxilline… vs Vehicle control and pre-drug baseline.
Design
Preclinical
Follow-up
Up to 4 days for in vivo experiments; up to 90 minutes for…
Authors
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Hypothesis-generating for BK channel effects on rodent heart rate; leaves open any translation to human electrophysiology or therapy.
Does inhibition of BK channels reduce heart rate in rodents?
Effect estimate: 30% to 42% reduction
p-value: p=<0.001
This study provides novel evidence that BK channels are directly involved in the regulation of heart rate, as their pharmacological inhibition significantly induces bradycardia in rodents.
Imlach et al. (2010) studied Normal cardiovascular function. BK channel inhibitors (paxilline and lolitrem B) vs. Vehicle control and BK channel knockout mice was evaluated on Heart rate (30% to 42% reduction, p=<0.001). Agents that specifically inhibit BK channel activity, including paxilline and lolitrem B, slowed heart rate in conscious wild-type mice by 30% and 42%, respectively.
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