May 10, 1994Biochemistry

Neuromodulin (GAP-43) Can Regulate a Calmodulin-Dependent Target in vitro

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Why the study?

Does neuromodulin regulate calmodulin-dependent nitric oxide synthase activity in vitro?

Population

In vitro model testing nitric oxide synthase (a calmodulin-dependent enzyme)

Comparison

Neuromodulin at varying concentrations… vs Absence of neuromodulin

Design

Preclinical

Authors

JSJ. Randall SlemmonUniversity of California, San Diego MMMark R. MartzenBastyr University

Discussion

Member takes

Implication

Should not yet change clinical practice; hypothesis-generating for neuromodulin as calmodulin regulator in neurons.

Structured PICO

Does neuromodulin regulate calmodulin-dependent nitric oxide synthase activity in vitro?

Population

In vitro model testing nitric oxide synthase (a calmodulin-dependent enzyme)

Intervention

Neuromodulin (GAP-43) at varying concentrations, including treatment with protein kinase C or calcineurin

Comparator

Absence of neuromodulin

Outcome

Nitric oxide synthase enzyme activitysurrogate

Neuromodulin (GAP-43) can inhibit calmodulin-dependent enzymes like nitric oxide synthase in vitro, suggesting a general regulatory role in neurons.

Cite This Study

Slemmon et al. (1994) studied this question.

synapsesocial.com/papers/6a847836880bd6494af7bc7e https://doi.org/10.1021/bi00184a039

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Neuromodulin (GAP-43) Can Regulate a Calmodulin-Dependent Target in vitro

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Neuromodulin (GAP-43) Can Regulate a Calmodulin-Dependent Target in vitro

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider