May 1, 1999Clinical Genetics

High frequency of de novo deletions in Mexican Duchenne and Becker muscular dystrophy patients. Implications for genetic counseling

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Population

Mexican Duchenne and Becker muscular dystrophy (DMD/BMD) patients and their families

Comparison

Quantitative polymerase chain reaction for… vs Linkage analysis

Design

Cross-sectional

Authors

MAMa Alcántara MVMt Villarreal VCV del Castillo

Discussion

Member takes

Implication

Supports direct carrier detection over linkage in Mexican DMD/BMD families; leaves open generalizability pending confirmatory studies.

Structured PICO

Population

Mexican Duchenne and Becker muscular dystrophy (DMD/BMD) patients and their families

Intervention

Quantitative polymerase chain reaction for direct carrier detection

Comparator

Linkage analysis

Outcome

Frequency of de novo deletions and carrier statussurrogate

The Mexican population has a high frequency of de novo DMD mutations, highlighting the importance of direct carrier detection methods like quantitative PCR over linkage analysis.

Cite This Study

Alcántara et al. (1999) studied this question.

synapsesocial.com/papers/6a84792374ee596ff2c52714 https://doi.org/10.1034/j.1399-0004.1999.550514.x

View Full Paper

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High frequency of de novo deletions in Mexican Duchenne and Becker muscular dystrophy patients. Implications for genetic counseling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

High frequency of de novo deletions in Mexican Duchenne and Becker muscular dystrophy patients. Implications for genetic counseling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider