Key result
Noninvasive estimation of glycated hemoglobin using a whole-finger digital volume pulse model demonstrated high accuracy with a mean absolute error of 0.271 and a Pearson's R of 0.96 compared to invasive measurements.
Why the study?
Glycated hemoglobin and blood oxygenation are critical for monitoring glucose and oxygen levels, and digital volume pulse acquisition offers a convenient method to noninvasively estimate these parameters.
Can digital volume pulse (DVP) waveforms accurately estimate noninvasive in-vivo percentage glycated hemoglobin and blood oxygenation in diabetic and nondiabetic patients?
Population
Diabetic and nondiabetic patients
Comparison
Blood-vessel-only model vs whole-finger model
Design
Model derivation and validation study
Authors
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DVP model shows high precision for noninvasive HbA1c/SpO2; hypothesis-generating and requires prospective validation before clinical use.
Observational (n=20)
No
Can digital volume pulse (DVP) waveforms accurately estimate noninvasive in-vivo percentage glycated hemoglobin and blood oxygenation in diabetic and nondiabetic patients?
Effect estimate: Pearson's R 0.96
A novel noninvasive whole-finger gray-box model using digital volume pulse waveforms can accurately estimate in-vivo glycated hemoglobin and blood oxygenation.
Hossain et al. (2021) conducted an observational in Diabetes mellitus (n=20). Digital volume pulse waveform analysis (whole-finger and blood-vessel models) vs. Invasive NGSP %HbA1c measurement was evaluated on Mean absolute error for %HbA1c estimation (Pearson's R 0.96). Noninvasive estimation of glycated hemoglobin using a whole-finger digital volume pulse model demonstrated high accuracy with a mean absolute error of 0.271 and a Pearson's R of 0.96 compared to invasive measurements.
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