Key result
Pre-operative moderate functional dependency was significantly associated with declining function at one year post-operatively (OR 17.5) in older adults undergoing colorectal cancer surgery.
Why the study?
Frailty is associated with increased postoperative morbidity, but few studies have investigated long-term functional outcomes.
Does functional frailty predict long-term disability better than medical frailty in older patients undergoing surgery for colorectal cancer?
Cohort (n=110)
No
Does functional frailty predict long-term disability better than medical frailty in older patients undergoing surgery for colorectal cancer?
Odds Ratio: 17.5 (95% CI 2.8–109.8)
Functional frailty, measured by the Barthel Index, is a better predictor of long-term functional decline and failure to return to baseline than medical frailty in older patients undergoing colorectal cancer surgery.
Functional frailty may inform preoperative risk stratification in older colorectal cancer patients; leaves open whether targeted interventions improve long-term outcomes.
BACKGROUND: Frailty has been associated with increased morbidity after surgery. However, few studies investigate long-term functional outcomes. METHODS: Patients ≥ 65 years old who underwent surgery for colorectal cancer were surveyed regarding their ability to perform activities of daily living, measured by Barthel Index, before and after surgery. Patients also reported time to return to their functional baseline. RESULTS: Pre-operative moderate dependency was associated with declining function at six months (OR: 8.8; CI: 1.8-42.6) and one year post-operatively (OR: 17.5; CI: 2.8-109.8). Pre-operative functional frailty was associated with subjective failure to return to baseline (OR: 4.8 and 4.2) for slightly and moderately dependent patients and a longer time to return to baseline. Medical frailty, based on the modified Frailty Index, was not significantly associated with failure to return to baseline. CONCLUSIONS: Measures of functional frailty are better predictors of failure to return to baseline, than measures of medical frailty.
No takes yet. Share an insight, caveat, or question.
Ginesi et al. (2022) conducted a cohort in Colorectal Cancer (n=110). Pre-operative moderate functional dependency vs. Pre-operative functional independence was evaluated on Declining function at one year post-operatively (OR 17.5, 95% CI 2.8-109.8). Pre-operative moderate functional dependency was significantly associated with declining function at one year post-operatively (OR 17.5) in older adults undergoing colorectal cancer surgery.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: