Key result
Postoperative hypoalbuminemia was associated with a higher incidence of pulmonary imaging abnormalities (41.1% vs 23.1%), with lower postoperative albumin serving as an independent predictor (OR 0.946).
Why the study?
Hypoalbuminemia is associated with poor surgical outcomes, prompting investigation into its incidence, risk factors, and impact on complications after brain tumor surgery.
Does postoperative hypoalbuminemia increase the risk of postoperative pulmonary imaging abnormalities and pneumonia in patients undergoing craniotomy for brain tumors?
Cohort (n=372)
No
Does postoperative hypoalbuminemia increase the risk of postoperative pulmonary imaging abnormalities and pneumonia in patients undergoing craniotomy for brain tumors?
Odds Ratio: 0.946 (95% CI 0.903–0.99)
Absolute Event Rate: 41.1% vs 23.1%
p-value: p=0.018
Postoperative hypoalbuminemia is highly prevalent after craniotomy for brain tumors and is associated with an increased risk of postoperative pulmonary imaging abnormalities, which in turn strongly predicts postoperative pneumonia.
Hypoalbuminemia-associated pulmonary abnormalities may increase post-craniotomy pneumonia risk; hypothesis-generating and requires prospective trials before practice change.
Hypoalbuminemia is associated with poor outcome in patients undergoing surgery intervention. The main aim for this study was to investigate the incidence and the risk factors of postoperative hypoalbuminemia and assessed the impact of postoperative hypoalbuminemia on complications in patients undergoing brain tumor surgery. This retrospective study included 372 consecutive patients who underwent brain tumors surgery from January 2017 to December 2019. The patients were divided into hypoalbuminemia (< 35 g/L) and non-hypoalbuminemia group (≥ 35 g/L) based on postoperative albumin levels. Logistic regression analyses were used to determine risk factors. Of the total 372 patients, 333 (89.5%) developed hypoalbuminemia after surgery. Hypoalbuminemia was associated with operation time (OR 1.011, P < 0.001), preoperative albumin (OR 0.864, P = 0.015) and peroperative globulin (OR 1.192, P = 0.004). Postoperative pulmonary imaging abnormalities had a higher incidence in patients with than without hypoalbuminemia (41.1% vs 23.1%, P = 0.029). The independent predictors of postoperative pulmonary imaging abnormalities were age (OR 1.053, P < 0.001), operation time (OR 1.003, P = 0.013) and lower postoperative albumin (OR 0.946, P = 0.018). Pulmonary imaging abnormalities [OR 19.862 (95% CI 2.546-154.936, P = 0.004)] was a novel independent predictors of postoperative pneumonia. Postoperative hypoalbuminemia has a higher incidence with the increase of operation time, and may be associated with postoperative complications in patients undergoing brain tumor surgery.
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Zhao et al. (2022) conducted a cohort in Brain tumors undergoing craniotomy (n=372). Postoperative hypoalbuminemia vs. Non-hypoalbuminemia was evaluated on Postoperative pulmonary imaging abnormalities (OR 0.946, 95% CI 0.903-0.990, p=0.018). Postoperative hypoalbuminemia was associated with a higher incidence of pulmonary imaging abnormalities (41.1% vs 23.1%), with lower postoperative albumin serving as an independent predictor (OR 0.946).
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