Key result
Monitoring the depth of general anaesthesia with a BIS monitor in children significantly shortened the period of recovery from anaesthesia from 5.1 to 4.1 minutes (p=0.0017).
Why the study?
Does monitoring the depth of general anaesthesia with a BIS monitor reduce the period of recovery from general anaesthesia in pediatric patients?
RCT (n=101)
Envelope method
No
Does monitoring the depth of general anaesthesia with a BIS monitor reduce the period of recovery from general anaesthesia in pediatric patients?
Absolute Event Rate: 4.1% vs 5.1%
p-value: p=0.0017
Monitoring the depth of general anaesthesia with a BIS monitor in children shortens the period of recovery from anaesthesia but does not decrease the consumption of inhalation anaesthetics.
BIS monitoring shortens pediatric recovery by 1 min; confirms RCT benefit and supports routine use in children.
Monitoring the depth of general anaesthesia (GA) enables the anaesthetist to reach the optimal depth of GA, and thus prevent the occurrence of too deep or too shallow anaesthesia, together with all associated consequences. Anaesthesia, which is too shallow, increases the risk of perioperative awareness. In adult patients, the incidence of perioperative awareness is 0.1-0.2 % for the total number of GA procedures, in paediatric population, the clinical studies present the incidence of up to 5 % (1973), 0.8 % (2005) for the total number of GA procedures. Perioperative awareness is a serious complication, with possible psychological consequences for the patients, including post-traumatic stress disorder. BIS monitoring is one of the possibilities how to assess the depth of GA. This technique is based on the assessment of EEG curve, when individual parameters of the EEG signal are, using mathematical methods, transformed into a dimensionless number, so-called bispectral index (BIS), the value of which is expressed on the scale from 0 to 100, and which reflects the depth of general anaesthesia. This prospective randomized clinical trial has proven, on a group of 101 children that the use of BIS monitor in the course of GA shortens the period of recovery from general anaesthesia, however, it does not decrease the consumption of inhalation anaesthetics when compared to GA performed without BIS monitoring. The results of the study confirmed the importance of monitoring the depth of GA in patients with intravenous administration of Propofol. The authors have observed an inverse linear relation between the values of BIS and MAC (minimum alveolar concentration).
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Divák et al. (2016) conducted an RCT in General anaesthesia for surgical procedures (n=101). BIS monitoring vs. No BIS monitoring was evaluated on Time of emergence from general anaesthesia (from end of surgical procedure to removal of airway device, in minutes) (p=0.0017). Monitoring the depth of general anaesthesia with a BIS monitor in children significantly shortened the period of recovery from anaesthesia from 5.1 to 4.1 minutes (p=0.0017).
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