Review highlights Oncostatin M regulation of lipid storage across insulin-sensitive tissues, suggesting distinct inflammatory mechanisms control metabolic function in liver and fat.
Oncostatin M (OSM) is a cytokine belonging to the gp130 family, whose members serve pleiotropic functions. However, several actions of OSM are unique from those of other gp130 cytokines, and these actions may have critical roles in inflammatory mechanisms influencing several metabolic and biological functions of insulin-sensitive tissues. In this review, the actions of OSM in adipose tissue and liver are discussed, with an emphasis on lipid metabolism.
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Elks et al. (2015) studied this question.
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