Variation in Protein and Polysaccharide Content of Sera in the Chronic Diseases, Tuberculosis, Sarcoidosis, and Carcinoma 1

It is well-known that marked changes may occur in the blood proteins in many diseases, and these changes have usually been expressed as variations in the albumin to globulin (A/G) ratio. In 1937, Tiselius ( 1) showed by means of the electro-phoresis technic that at least 3 distinctly different globulins can be distinguished in serum, and later work (2) made it possible to measure them quanti-tatively from their electrophoretic diagrams. Fur-thermore, it has been shown that the relative amounts of these different protein components vary considerably in different diseases. For example, various pathological sera and plasmas were studied with this technic by Longsworth, Shedlovsky and MacInnes (3); pneumonia sera, by Blix (4);