Highlights the management challenges and importance of multidisciplinary care for pregnant women with Marfan's syndrome.
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Case report supports multidisciplinary screening in Marfan pregnancies; leaves open need for prospective validation before practice change.
SummaryMarfan's syndrome is a connective tissue disorder with autosomal dominant inheritance. Death from the disorder is most commonly due to a cardiovascular complication—aortic dissection or heart failure secondary to valvular insufficiency. Sufferers are at an increased risk of complications during pregnancy necessitating close fetal and maternal surveillance by a multidisciplinary team including obstetrician, cardiologist and geneticist. We report the reproductive performance of two generations of women with Marfan's syndrome, highlighting the importance of careful genetic and clinical screening in optimising their care, and our views on the management challenges which this syndrome poses.
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Anumba et al. (1994) studied this question.
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