Key result
Preconceptional mitral and tricuspid valve correction in Marfan syndrome is linked to two uneventful pregnancies.
Case Report (n=1)
Preconceptional surgical correction of valve defects and appropriate use of beta-blockers in women with Marfan syndrome may decrease the risk of cardiac decompensation and aortic rupture during future pregnancies.
May support individualized preconceptional valve surgery in Marfan syndrome; hypothesis-generating and should not yet change practice.
Marfan syndrome is an autosomal dominant disorder of connective tissue with up to 25% of cases related to a spontaneous mutation. It has been associated with perinatal loss, preterm labor and, potentially a rupture of the maternal aortic arch. We present a case of a woman diagnosed with Marfan syndrome after a miscarriage of her first pregnancy. At the time of diagnosis she had mild aortic bulb dilation and insufficiency of the mitral and tricuspid valves. She underwent cardiosurgical correction, after which she had two uneventful pregnancies. This case suggests that preconceptional correction of valve defects in women with Marfan syndrome may decrease the risk of cardiac decompensation during future pregnancies. Additionally close clinical follow up and the appropriate use of beta-adrenergic blockade may decrease the risk of aortic rupture, a significant risk factor for mortality in pregnant women.
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Zamłyński et al. (2013) conducted a case report in Marfan syndrome (n=1). Cardiosurgical correction of mitral and tricuspid valve insufficiency was evaluated on Pregnancy outcomes. Preconceptional cardiosurgical correction of mitral and tricuspid valve defects in a woman with Marfan syndrome was followed by two uneventful pregnancies.
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