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December 1, 2016Cell ReportsOpen Access

Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells

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Authors

XLXiaolin LuoSun Yat-sen UniversityRLRui LiaoArmy Medical UniversityKHKaisa L. HanleyUniversity of California, San Diego

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Luo et al. (2016) studied this question.

synapsesocial.com/papers/6a84837b7e95b97f4e730801https://doi.org/10.1016/j.celrep.2016.11.048
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Shp-2 Tyrosine Phosphatase Has Opposite Effects in Mediating the Activation of Extracellular Signal-regulated and c-Jun NH2-terminal Mitogen-activated Protein Kinases1998 · 156 citations
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  3. 3Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype2006 · 402 citations
  4. 4Expression of TREM ‐1 in hepatic stellate cells and prognostic value in hepatitis B ‐related hepatocellular carcinoma2012 · 82 citations
  5. 5Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals2015 · 14 citations