May 1, 2000Genes & DevelopmentOpen Access

Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon–exon junctions

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Population

in vitro models of pre-mRNA splicing

Design

Preclinical

Authors

HHHervé Le HirCentre National de la Recherche Scientifique MMMelissa J. MooreUniversity of Massachusetts Chan Medical School LMLynne E. MaquatUniversity of Rochester

Discussion

Member takes

Implication

May mark spliced mRNAs for transport, translation, or decay; leaves open functional roles in mammalian disease models.

Structured PICO

Population

in vitro models of pre-mRNA splicing

Intervention

in vitro cross-linking approach, immunoprecipitation, and glycerol gradient fractionation

Outcome

detection of proteins associated with mRNA exon-exon junctions as a consequence of splicingsurrogate

Pre-mRNA splicing alters mRNP composition by leaving signature proteins at exon-exon junctions, which may influence downstream metabolic events such as mRNA transport, translation, and nonsense-mediated decay.

Cite This Study

Hir et al. (2000) studied this question.

synapsesocial.com/papers/6a8486fda47fb2e1cdb2b092 https://doi.org/10.1101/gad.14.9.1098

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Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon–exon junctions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon–exon junctions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider