Key result
Of 14,657 patients with suspected enteroviral disease in South Korea from 1999 to 2011, 32.5% tested positive for human enterovirus, with detection rates increasing as diagnostic methods improved.
Observational (n=14,657)
Yes
The transition to advanced molecular diagnostic methods significantly improved the detection sensitivity of human enterovirus and enabled accurate correlation between specific genotypes and clinical syndromes.
Improved molecular diagnostics boost enterovirus detection and enable genotype-syndrome correlations; hypothesis-generating and leaves open prospective validation before guiding practice.
The epidemiology of enteroviral infection in South Korea during 1999-2011 chronicles nationwide outbreaks and changing detection and subtyping methods used over the 13-year period. Of 14,657 patients whose samples were tested, 4,762 (32.5%) samples were positive for human enterovirus (human EV); as diagnostic methods improved, the rate of positive results increased. A seasonal trend of outbreaks was documented. Genotypes enterovirus 71, echovirus 30, coxsackievirus B5, enterovirus 6, and coxsackievirus B2 were the most common genotypes identified. Accurate test results correlated clinical syndromes to enterovirus genotypes: aseptic meningitis to echovirus 30, enterovirus 6, and coxsackievirus B5; hand, foot and mouth disease to coxsackievirus A16; and hand, foot and mouth disease with neurologic complications to enterovirus 71. There are currently no treatments specific to human EV infections; surveillance of enterovirus infections such as this study provides may assist with evaluating the need to research and develop treatments for infections caused by virulent human EV genotypes.
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Hyeon et al. (2013) conducted an observational in Suspected enteroviral disease (n=14,657). Human enterovirus infection was evaluated on Prevalence of human enterovirus (EV) positive patients. Of 14,657 patients with suspected enteroviral disease in South Korea from 1999 to 2011, 32.5% tested positive for human enterovirus, with detection rates increasing as diagnostic methods improved.
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