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Hepatorenal and hepatointestinal reflexes with receptors in the hepatoportal region transduce portal plasma Na+ concentration into hepatic afferent nerve activity and reflexively augment renal Na+ excretion and attenuate intestinal Na+ absorption before a measurable increase in systemic Na+ concentration. These reflexes contribute to Na+ homeostasis in a negative, "feedforward" fashion.
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Hosomi et al. (1996) studied this question.
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